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MAD even attacked the subtle details of things like the proportions of cereal boxes. Every manipulative detail of the ad-biz was ridiculed and laid bare.
Most substantially, MAD magazine itself had no third-party ads from 1957 through 2001. This practice went against all business assumptions about the publishing industry. They did everything backwards. Cheaper paper, black-and-white, no ads, and they purchased the rights to submitted artwork outright so they could use and reuse it freely. They savagely satirized all of America's consumer culture, ad-biz, and celebrity obsessions. Their interests were aligned solely with the readership.